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KMID : 0605720170230030230
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Journal of the Korean Society of Biological Therapies in Psychiatry
2017 Volume.23 No. 3 p.230 ~ p.239
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Comparison of Anxiety Sensitivity and Panic-Related Symptoms between Depressive Patients with and without Bipolarity
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Lim Jong-Gil
Kang Tae-Uk
Moon Eun-Soo
Park Je-Min
Lee Byung-Dae
Lee Young-Min
Jeong Hee-Jeong
Choi Yoon-MI
Park Young-Min
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Abstract
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Objectives：A few studies have shown that some anxiety disorders, especially panic disorder, are more related with bipolar than with unipolar depressive disorder. However, there is lack of evidence on the different patterns of anxiety sensitivity and panic-related symptoms, depending on bipolarity in patients with depression. This study was aimed at comparing anxiety sensitivity and panic-related symptoms between patients with depression with and without bipolarity.
Methods：We recruited 158 patients who experiencing depressive disorders. Bipolarity was evaluated with the Mood Disorder Questionnaire(MDQ). Panic-related symptoms and anxiety sensitivity were measured with the Anxiety Sensitivity Index-Revised(ASI-R), Acute Panic Inventory(API) and Korea Albany Panic and Phobia Questionnaire(K-APPQ). Anxiety sensitivity and panic-related symptoms were compared between patients with depression with positive and negative screen in the MDQ using independent t-test and analysis of covariance(ANCOVA).
Results：Patients with depression who had a positive screen on the MDQ had higher ASI-R total and subscales scores(total score, p=0.012; fear of publicly observable anxiety reactions, p=0.002; fear of cognitive dyscontrol, p=0.009), API score(p=0.005), rate of API score with more than 20 points(p=0.021) than those with negative results on the MDQ. After adjust for age and Beck Depression Inventory(BDI) score, the differences between the two groups remained significant(ASI-R total score, p=0.012 ; ASI-R fear of publicly observable anxiety reactions, p=0.008 ; ASI-R fear of cognitive dyscontrol, p=0.012; API score, p=0.017). Additionally, a significant difference in the ASI-R subscale, fear of cardiovascular symptoms appeared between the two groups after adjusting for age and BDI score(p=0.042).
Conclusion：The results suggested that the presence of bipolarity in patients with depression may be related to the frequency of panic symptoms and high anxiety sensitivity. The presence of bipolarity may need to be considered in treating comorbid panic disorder in patients with depression.
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KEYWORD
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Panic symptom, Anxiety sensitivity, Bipolarity, Bipolar spectrum disorder, MDQ
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